Characterization of Phosphorylated Targets in Ovarian Cancer

Abstract

Unspecific symptoms lead to diagnosis of ovarian cancer (OC) at an advanced stage. We believe that the treatment with chemotherapy cycles induces resistance in patients through rewiring of the kinome pathways. In this study, we have generated combinational chemo-resistant OC cell lines to identify kinases as potential drug targets in resistant subtypes. These findings were also validated in HGSOC patients’ samples. We aim to improve drug sensitivity and treatment for patients with acquired chemoresistance.