Exploring the Effects of the Long Noncoding RNA MIR205HG on PI3K Inhibitor Resistance in Breast Cancer

Vasilevski, Natali

Access Status

Fulltext not available

Embargo Lift Date

2027-05-19

Authors

Vasilevski, Natali

Date

2025

Supervisor

Pieter Eichhorn

Nina Tirnitz-Parker

Rodrigo Carlessi

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Curtin Medical School

URI

http://hdl.handle.net/20.500.11937/97830

Collection

Curtin Theses

Abstract

Breast cancer is a leading cause of cancer death worldwide, with nearly 21,000 cases predicted in Australia for 2024. A key driver is the PI3K pathway, often hyperactivated due to PIK3CA mutations or loss of the tumor suppressor PTEN. Resistance to PI3K inhibitors is common, but long noncoding RNAs (lncRNAs) like MIR205HG may play a role. This study found that losing MIR205HG increased resistance but made cells vulnerable to prolonged PI3K inhibition, revealing a potential therapeutic strategy.