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    Exploring the Effects of the Long Noncoding RNA MIR205HG on PI3K Inhibitor Resistance in Breast Cancer

    Access Status
    Fulltext not available
    Embargo Lift Date
    2027-05-19
    Authors
    Vasilevski, Natali
    Date
    2025
    Supervisor
    Pieter Eichhorn
    Nina Tirnitz-Parker
    Rodrigo Carlessi
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/97830
    Collection
    • Curtin Theses
    Abstract

    Breast cancer is a leading cause of cancer death worldwide, with nearly 21,000 cases predicted in Australia for 2024. A key driver is the PI3K pathway, often hyperactivated due to PIK3CA mutations or loss of the tumor suppressor PTEN. Resistance to PI3K inhibitors is common, but long noncoding RNAs (lncRNAs) like MIR205HG may play a role. This study found that losing MIR205HG increased resistance but made cells vulnerable to prolonged PI3K inhibition, revealing a potential therapeutic strategy.

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