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    Aspirin in a novel mouse model of metabolic steatotic liver disease and its potential to prevent hepatocellular carcinoma

    Access Status
    Fulltext not available
    Embargo Lift Date
    2027-07-29
    Authors
    Abu Bakar, Nur Dianah Binte
    Date
    2025
    Supervisor
    Nina Tirnitz-Parker
    Rodrigo Carlessi
    Ricky Lareu
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/98186
    Collection
    • Curtin Theses
    Abstract

    Aspirin shows promise as an accessible approach for preventing liver disease and hepatocellular carcinoma (HCC). Using mouse models combining gene editing and a NASH-inducing diet, aspirin reduced liver inflammation, fibrosis, oxidative stress, and hypoxia, while shifting immune cell profiles toward tissue repair. Key targets included COX-1 and hypoxia pathways. These findings highlight aspirin’s potential as a protective agent in chronic liver disease management and warrant further investigation into its mechanisms and role in HCC prevention.

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