Aspirin in a novel mouse model of metabolic steatotic liver disease and its potential to prevent hepatocellular carcinoma
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Fulltext not available
Embargo Lift Date
2027-07-29
Date
2025Supervisor
Nina Tirnitz-Parker
Rodrigo Carlessi
Ricky Lareu
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
Curtin Medical School
Collection
Abstract
Aspirin shows promise as an accessible approach for preventing liver disease and hepatocellular carcinoma (HCC). Using mouse models combining gene editing and a NASH-inducing diet, aspirin reduced liver inflammation, fibrosis, oxidative stress, and hypoxia, while shifting immune cell profiles toward tissue repair. Key targets included COX-1 and hypoxia pathways. These findings highlight aspirin’s potential as a protective agent in chronic liver disease management and warrant further investigation into its mechanisms and role in HCC prevention.
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