Clinical pharmacology studies of benzathine benzylpenicillin and benzylpenicillin

Abstract

This thesis investigates the clinical use of benzathine penicillin G (BPG) in rheumatic heart disease and syphilis management, focusing on delivery constraints, safety concerns, and pharmacokinetics. Through qualitative research, systematic review, and population pharmacokinetic modeling, it examines provider apprehensions, logistical challenges, adverse reactions, and maternal pharmacokinetics. Despite BPG’s efficacy and favorable pharmacologic profile, findings underscore the need for optimized formulations, robust supply chains, and enhanced pharmacovigilance to ensure safer, more effective utilization, particularly in resource-limited settings.