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    Is the soleus a sentinel muscle for impaired aerobic capacity in heart failure?

    Access Status
    Open access via publisher
    Authors
    Panizzolo, F.
    Maiorana, Andrew
    Naylor, L.
    Lichtwark, G.
    Dembo, L.
    Lloyd, D.
    Green, D.
    Rubenson, J.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Panizzolo, F. and Maiorana, A. and Naylor, L. and Lichtwark, G. and Dembo, L. and Lloyd, D. and Green, D. et al. 2015. Is the soleus a sentinel muscle for impaired aerobic capacity in heart failure?. Medicine and Science in Sports and Exercise. 47 (3): pp. 498-508.
    Source Title
    Medicine and Science in Sports and Exercise
    DOI
    10.1249/MSS.0000000000000431
    ISSN
    0195-9131
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/10302
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: Skeletal muscle wasting is well documented in chronic heart failure (CHF). This article provides a more detailed understanding of the morphology behind this muscle wasting and the relation between muscle morphology, strength, and exercise capacity in CHF. We investigated the effect of CHF on lower limb lean mass, detailed muscle-tendon architecture of the individual triceps surae muscles (soleus (SOL), medial gastrocnemius, and lateral gastrocnemius) and how these parameters relate to exercise capacity and strength. Methods: Eleven patients with CHF and 15 age-matched controls were recruited. Lower limb lean mass was assessed by dual energy x-ray absorptiometry and the architecture of skeletal muscle and tendon properties by ultrasound. Plantarflexor strength was assessed by dynamometry. Results: Patients with CHF exhibited approximately 25% lower combined triceps surae volume and physiological cross-sectional area (PCSA) compared with those of control subjects (P < 0.05), driven in large part by reductions in the SOL. Only the SOL volume and the SOL and medial gastrocnemius physiological cross-sectional area were statistically different between groups after normalizing to lean body mass and body surface area, respectively. Total lower limb lean mass did not differ between CHF and control subjects, further highlighting the SOL specificity of muscle wasting in CHF. Moreover, the volume of the SOL and plantarflexor strength correlated strongly with peak oxygen uptake (V.O2peak) in patients with CHF. Conclusions: These findings suggest that the SOL may be a sentinel skeletal muscle in CHF and provide a rationale for including plantarflexor muscle training in CHF care.

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