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    Development of a Pharmacodynamic Model of Murine Malaria

    238410_Gibbons 2015.pdf (9.536Mb)
    Access Status
    Open access
    Authors
    Gibbons, Peter Luke
    Date
    2015
    Supervisor
    Dr Andrew Crowe
    Prof. Kevin Batty
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/1031
    Collection
    • Curtin Theses
    Abstract

    The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic data and novel in silico mathematical model enabling optimisation of dosing and combination therapy. These models contribute to preclinical knowledge and provide the potential to assist in the development of methods to optimise clinical treatment.

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