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dc.contributor.authorGibbons, Peter Luke
dc.contributor.supervisorDr Andrew Crowe
dc.contributor.supervisorProf. Kevin Batty

The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic data and novel in silico mathematical model enabling optimisation of dosing and combination therapy. These models contribute to preclinical knowledge and provide the potential to assist in the development of methods to optimise clinical treatment.

dc.publisherCurtin University
dc.titleDevelopment of a Pharmacodynamic Model of Murine Malaria
curtin.departmentSchool of Pharmacy
curtin.accessStatusOpen access

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