Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus
|dc.identifier.citation||Jin, X. and Zeng, L. and Zhang, S. and He, S. and Ren, Y. and Chen, Y. and Wei, L. et al. 2013. Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus. Journal of Medical Primatology. 42 (1): pp. 1-9.|
Monkeys with insulin-dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long-term vascular complications associated with diabetes until the graft function recovered completely. However, the effect of multiple daily injections of porcine or human insulin and the long-term effects of porcine insulin have not been studied in diabetic rhesus monkeys. Methods: Diabetic rhesus monkeys, using a 6-month self-control insulin comparison experiment, were used to detect the incidence of adverse events and long-term diabetes complication events after long-term administration of porcine insulin. Results: In this study, we found that a 20% higher dose of porcine insulin results in similar glycemic control as the human insulin regimen, and adverse events were seldom reported when porcine insulin was administered. Moreover, long-term injection with porcine insulin could delay the rate and severity of diabetes-related complications. Conclusions: Porcine insulin as a competent candidate for regular insulin therapy to maintain blood glucose levels in insulin-dependent diabetic monkeys during preclinical studies of islet transplantation. © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
|dc.title||Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus|
|dcterms.source.title||Journal of Medical Primatology|
|curtin.department||School of Biomedical Sciences|
|curtin.accessStatus||Fulltext not available|
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