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    The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease

    Access Status
    Fulltext not available
    Authors
    Tan, D.
    Fernandez, S.
    Price, Patricia
    Moodley, Y.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Tan, D. and Fernandez, S. and Price, P. and Moodley, Y. 2014. The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease. Human Immunology. 75 (1): pp. 5-9.
    Source Title
    Human Immunology
    DOI
    10.1016/j.humimm.2013.09.011
    ISSN
    01988859
    URI
    http://hdl.handle.net/20.500.11937/10768
    Collection
    • Curtin Research Publications
    Abstract

    Myeloid-derived suppressor cells (MDSC) have been implicated in the regulation of chronic inflammation. Chronic obstructive pulmonary disease (COPD) involves persistent inflammation, but the role of MDSC has not been explored. Here, proportions of MDSC (CD14-HLA-DR-CD33+CD11b+ cells) were quantified in peripheral blood mononuclear cells (PBMC) isolated from patients with ‘stable’ COPD (n = 12), smokers with no evidence of COPD (n = 11) and healthy non-smokers (n = 11). The proportions of MDSC were similar in all groups. MDSC function was assessed by comparing T-cell and cytokine responses of whole and MDSC-depleted PBMC stimulated with Staphylococcus enterotoxin-B (SEB). Depletion of MDSC did not enhance CD4+ or CD8+ T-cell activation and proliferation, or alter IFN? and IL-17 production in response to SEB. However production of TGFß decreased after depletion of MDSC, so MDSC may be a source of this cytokine. In conclusion, COPD was not associated with perturbations in the proportion or function of MDSC in peripheral blood.

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