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dc.contributor.authorBoan, P.
dc.contributor.authorTan, H.
dc.contributor.authorPearson, J.
dc.contributor.authorCoombs, Geoffrey
dc.contributor.authorHeath, C.
dc.contributor.authorRobinson, J.
dc.date.accessioned2017-01-30T11:21:05Z
dc.date.available2017-01-30T11:21:05Z
dc.date.created2015-10-29T04:09:56Z
dc.date.issued2015
dc.identifier.citationBoan, P. and Tan, H. and Pearson, J. and Coombs, G. and Heath, C. and Robinson, J. 2015. Epidemiological, clinical, outcome and antibiotic susceptibility differences between PVL positive and PVL negative Staphylococcus aureus infections in Western Australia: A case control study. BMC Infectious Diseases. 15 (10): pp. 1-6.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/10809
dc.identifier.doi10.1186/s12879-014-0742-6
dc.description.abstract

Background: Panton Valentine Leukocidin (PVL) has been associated with invasive Staphylococcus aureus soft tissue and pneumonic infections. Methods: From September 2007 to January 2009 at Royal Perth Hospital we tested for the PVL gene in S. aureus isolates from an invasive site, a suspected PVL-related soft tissue infection and all MRSA isolates. We could access medical records for 141 PVL positive (PVL + ve) infections and compared these to a control group comprised of 148 PVL negative (PVL-ve) infections. Results: In the PVL + ve group 62 isolates were MRSA (48 were ST93-MRSA-IV) and 79 isolates were methicillin-sensitive S. aureus, and in the PVL-ve group 56 were MRSA (50 were WA-MRSA strains) and 92 were methicillin-sensitive S. aureus. We found the presence of PVL to be significantly associated with younger age, aboriginality, intravenous drug use, community acquisition, shorter length of hospital stay and lower mortality at 1 year. Overall PVL + ve infections more often required surgical intervention (73.0% versus 44.6%, p < 0.001) and were less often polymicrobial (8.5% versus 41.2%, p < 0.001). PVL + ve isolates were more often susceptible to clindamycin (87.9% versus 73.0%, p = 0.002). Conclusions: This study demonstrates that PVL + ve infections are associated with a distinct clinical picture, predominantly pyogenic skin and soft tissue infections often requiring surgery, disproportionately affecting patients who are younger, indigenous or with fewer health-care risk factors.

dc.publisherBioMed Central Ltd.
dc.titleEpidemiological, clinical, outcome and antibiotic susceptibility differences between PVL positive and PVL negative Staphylococcus aureus infections in Western Australia: A case control study
dc.typeJournal Article
dcterms.source.volume15
dcterms.source.number1
dcterms.source.titleBMC Infectious Diseases
curtin.note

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


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