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dc.contributor.authorShen, Y.
dc.contributor.authorWard, Natalie
dc.contributor.authorHodgson, J.
dc.contributor.authorPuddey, I.
dc.contributor.authorWang, Y.
dc.contributor.authorZhang, D.
dc.contributor.authorMaghzal, G.
dc.contributor.authorStocker, R.
dc.contributor.authorCroft, K.
dc.date.accessioned2017-01-30T11:22:12Z
dc.date.available2017-01-30T11:22:12Z
dc.date.created2016-01-19T20:00:32Z
dc.date.issued2013
dc.identifier.citationShen, Y. and Ward, N. and Hodgson, J. and Puddey, I. and Wang, Y. and Zhang, D. and Maghzal, G. et al. 2013. Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein e knockout mice fed a high-fat diet: A critical role for heme oxygenase-1. Free Radical Biology and Medicine. 65: pp. 908-915.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/10995
dc.identifier.doi10.1016/j.freeradbiomed.2013.08.185
dc.description.abstract

Several lines of evidence indicate that quercetin, a polyphenol derived in the diet from fruit and vegetables, contributes to cardiovascular health. We aimed to investigate the effects of dietary quercetin on endothelial function and atherosclerosis in mice fed a high-fat diet. Wild-type C57BL/6 (WT) and apolipoprotein E gene knockout (ApoE−/−) mice were fed: (i) a high-fat diet (HFD) or (ii) a HFD supplemented with 0.05% w/w quercetin (HFD+Q), for 14 weeks. Compared with animals fed HFD, HFD+Q attenuated atherosclerosis in ApoE−/− mice. Treatment with the HFD+Q significantly improved endothelium-dependent relaxation of aortic rings isolated from WT but not ApoE−/− mice and attenuated hypochlorous acid-induced endothelial dysfunction in aortic rings of both WT and ApoE−/− mice. Mechanistic studies revealed that HFD+Q significantly improved plasma F2-isoprostanes, 24 h urinary nitrite, and endothelial nitric oxide synthase activity, and increased heme oxygenase-1 (HO-1) protein expression in the aortas of both WT and ApoE−/− mice (P<0.05). HFD+Q also resulted in small changes in plasma cholesterol (P<0.05 in WT) and plasma triacylglycerols (P<0.05 in ApoE −/−mice). In a separate experiment, quercetin did not protect against hypochlorite-induced endothelial dysfunction in arteries obtained from heterozygous HO-1 gene knockout mice with low expression of HO-1 protein. Quercetin protects mice fed a HFD against oxidant-induced endothelial dysfunction and ApoE−/− mice against atherosclerosis. These effects are associated with improvements in nitric oxide bioavailability and are critically related to arterial induction of HO-1.

dc.titleDietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein e knockout mice fed a high-fat diet: A critical role for heme oxygenase-1
dc.typeJournal Article
dcterms.source.volume65
dcterms.source.startPage908
dcterms.source.endPage915
dcterms.source.issn0891-5849
dcterms.source.titleFree Radical Biology and Medicine
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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