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dc.contributor.authorKeane, Kevin
dc.contributor.authorCruzat, Vinicius
dc.contributor.authorCarlessi, Rodrigo
dc.contributor.authorIvo, P.
dc.contributor.authorDe Bittencourt, P.
dc.contributor.authorNewsholme, Philip
dc.identifier.citationKeane, K. and Cruzat, V. and Carlessi, R. and Ivo, P. and de Bittencourt, P. and Newsholme, P. 2015. Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and ß-Cell Dysfunction. Oxidative Medicine and Cellular Longevity. 2015: Article ID 181643.

The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM). Unresolved inflammation alongside a “glucolipotoxic” environment of the pancreatic islets, in insulin resistant pathologies, enhances the infiltration of immune cells which through secretory activity cause dysfunction of insulin-secreting β-cells and ultimately cell death. Recent molecular investigations have revealed that mechanisms responsible for insulin resistance associated with T2DM are detected in conditions such as obesity and MetS, including impaired insulin receptor (IR) signalling in insulin responsive tissues, oxidative stress, and endoplasmic reticulum (ER) stress. The aim of the present review is to describe the evidence linking oxidative stress and inflammation with impairment of insulin secretion and action, which result in the progression of T2DM and other conditions associated with metabolic dysregulation.

dc.publisherHindawi Publishing Corporation
dc.titleMolecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and ß-Cell Dysfunction
dc.typeJournal Article
dcterms.source.titleOxidative Medicine and Cellular Longevity

This open access article is distributed under the Creative Commons license

curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access

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