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    Metagenomic strategies for the discovery of novel enzymes with biotechnological application from marine ecosystems

    Access Status
    Fulltext not available
    Authors
    Kennedy, J.
    Margassery, L.
    Morrissey, J.
    O'Gara, Fergal
    Dobson, A.
    Date
    2013
    Type
    Book Chapter
    
    Metadata
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    Citation
    Kennedy, Jonathan and Margassery, Lekha Menon and Morrissey, John P. and O'Gara, Fergal and Dobson, Alan D.W.. 2013. Metagenomic strategies for the discovery of novel enzymes with biotechnological application from marine ecosystems, in Trincone, A. (ed), Marine Enzymes for Biocatalysis: Sources, biocatalytic characteristsics and bioprocesses of marine enzymes, pp. 109-130. Cambridge: Woodhead Publishing.
    Source Title
    Marine Enzymes for Biocatalysis
    DOI
    10.1533/9781908818355.2.109
    ISBN
    9781907568800
    9781908818355
    URI
    http://hdl.handle.net/20.500.11937/11064
    Collection
    • Curtin Research Publications
    Abstract

    As a consequence of its geochemical and geophysical variability, the marine environment, which is dominated by microorganisms and their viruses, also possesses the greatest diversity of biological life on the planet. The habitats of these microbes range from the harshest of environments in the deep ocean to intimate symbiotic associations with other marine organisms. This ecological diversity leads, in turn, to metabolic diversity and it is now accepted that marine microbes contain a vast reservoir of novel enzymes and metabolites that can be of benefit to society. The challenge is in accessing, exploring, and ultimately exploiting this potential reservoir. A major obstacle to date has been the limited capacity to culture marine microbes but genomic and metagenomic technologies now offer promising new strategies for marine biodiscovery. In this chapter, the different sequence and function- based approaches that can be taken are described and assessed. There have been some modest successes in identifying new enzymes but significant hurdles remain. This is, however, a field in its infancy and one which is moving rapidly. It is likely, however, that on- going and future development of new methodologies for screening and expressing marine bacterial genes is likely to yield many new enzymes with novel properties.

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