Genetics of Attention Deficit Hyperactivity Disorder: A current review and future prospects
MetadataShow full item record
While there have been significant advances in both the behaviour genetics and molecular genetics of Attention Deficit Hyperactivity Disorder (ADHD), researchers are now beginning to develop hypotheses about relationships between phenotypes and genetic mechanisms. Twin studies are able to model genetic, shared environmental and non-shared environmental influences on aetiology. The present review describes recent behaviour genetic and latent class findings in relation to ADHD and its subtypes, including rater effects, comorbidity, and developmental effects, which have an impact on findings of high heritability. Molecular genetic studies have predominantly focused on dopamine genes, including dopamine receptor and transporter genes, because of animal and human studies indicating the importance of dopaminergic attention systems. The recent clinical use of noradrenergic reuptake inhibitors has also increased interest in noradrenergic genes. Adult ADHD and age-related genetic effects, in addition to “reading” genes, are reviewed in relation to comorbidity and developmental effects.
Showing items related by title, author, creator and subject.
Analysis of candidate genes within the 3p14-p22 region of the human genome for association with bone mineral density phenotypesMullin, Benjamin H (2011)Previous studies have identified the 3p14-p22 chromosomal region as a quantitative trait locus for bone mineral density (BMD). The overall aim of this thesis is to identify the gene or genes from this region that are ...
Alawadhi, Sohaila (2010)Background: According to the United Kingdom prospective diabetes study, metformin is considered the drug of choice in overweight newly diagnosed type 2 diabetic patients. Metformin is well characterized as a substrate of ...
Australian twin and molecular genetic study on attention deficit hyperactivity disorder and its co-morbidity with reading disabilitySheikhi, Abdullah (2008)Aim: This study aims to investigate the genetic components of Attention Deficit Hyperactivity Disorder (ADHD), Reading Disability (RD), and their comorbidity. Methods: Three approaches were applied to data from 2610 ...