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    Iron and Hepatic Carcinogenesis

    Access Status
    Fulltext not available
    Authors
    Tirnitz-Parker, Janina
    Glanfield, A.
    Olynyk, John
    Ramm, G.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Tirnitz-Parker, Janina E.E. and Glanfield, Amber and Olynyk, John K. and Ramm, Grant A. 2013. Iron and Hepatic Carcinogenesis. Critical Reviews in Oncogenesis. 18 (5): pp. 391-407.
    Source Title
    Critical Reviews in Oncogenesis
    DOI
    10.1615/CritRevOncog.2013007759
    ISSN
    0893-9675
    URI
    http://hdl.handle.net/20.500.11937/11138
    Collection
    • Curtin Research Publications
    Abstract

    Iron is an essential co-factor for life; however, a physiologically optimal balance is critical. Too much or too little iron can have detrimental effects on human health. In this article, we explore the relationships between iron and hepatocellular carcinoma (HCC). Iron can act as a modulating co-factor in a range of chronic liver diseases and can accelerate the development of liver injury, fibrosis, cirrhosis, and ultimately HCC. Iron can, however, also act as a sole factor in the causation of liver cirrhosis and HCC in individuals with hereditary hemochromatosis (HH). We overview the regulation of normal iron metabolism and the role of iron in wound healing and associated cell types as well as in pathophysiologies that predispose to HCC. We review how these injury pro- cesses are inextricably linked, providing a mechanistic basis for understanding how iron and hepatic injury potentially result in HCC.

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