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    Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

    Access Status
    Fulltext not available
    Authors
    Ruban, E.
    Ferro, R.
    Arifin, S.
    Falasca, Marco
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Ruban, E. and Ferro, R. and Arifin, S. and Falasca, M. 2014. Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors. Biochemical Society. Transactions. 42 (5): pp. 1372-1377.
    Source Title
    Biochemical Society. Transactions
    DOI
    10.1042/BST20140151
    ISSN
    0300-5127
    URI
    http://hdl.handle.net/20.500.11937/11188
    Collection
    • Curtin Research Publications
    Abstract

    Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation.

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