Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    INSIG1 infl uences obesity-related hypertriglyceridemia in humans

    Access Status
    Open access via publisher
    Authors
    Smith, E.
    Zhang, Y.
    Baye, T.
    Gawrieh, S.
    Cole, R.
    Blangero, J.
    Carless, M.
    Curran, J.
    Dyer, T.
    Abraham, L.
    Moses, Eric
    Kissebah, A.
    Martin, L.
    Olivier, M.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Smith, E. and Zhang, Y. and Baye, T. and Gawrieh, S. and Cole, R. and Blangero, J. and Carless, M. et al. 2010. INSIG1 infl uences obesity-related hypertriglyceridemia in humans. Journal of Lipid Research. 51 (4): pp. 701-708.
    Source Title
    Journal of Lipid Research
    DOI
    10.1194/jlr.M001404
    ISSN
    0022-2275
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/11309
    Collection
    • Curtin Research Publications
    Abstract

    In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the region. Insulin-induced genes (INSIG s) are feedback mediators of cholesterol and fatty acid synthesis in animals, but their role in human lipid regulation is unclear. In our cohort, the INSIG1 promoter SNP rs2721 was associated with TG levels (P = 2 × 10 3 in 1,560 individuals of the original linkage cohort, P = 8 × 10 4 in 920 unrelated individuals of the replication cohort, combined P = 9.9 × 10 6). Individuals homozygous for the T allele had 9% higher TG levels and 2-fold lower expression of INSIG1 in surgical liver biopsy samples when compared with individuals homozygous for the G allele. Also, the T allele showed additional binding of nuclear proteins from HepG2 liver cells in gel shift assays. Finally, the variant rs7566605 in INSIG2, the only homolog of INSIG1, enhances the effect of rs2721 (P = 0.00117). The variant rs2721 alone explains 5.4% of the observed linkage in our cohort, suggesting that additional, yet-undiscovered genes and sequence variants in the QTL interval also contribute to alterations in TG levels in humans. Copyright © 2010 by the American Society for Biochemistry and Molecular Biology, Inc.

    Related items

    Showing items related by title, author, creator and subject.

    • Genetic variation at the FTO locus influences RBL2 gene expression
      Jowett, J.; Curran, J.; Johnson, M.; Carless, M.; Göring, H.; Dyer, T.; Cole, S.; Comuzzie, A.; MacCluer, J.; Moses, Eric; Blangero, J. (2010)
      OBJECTIVE - Genome-wide association studies that compare the statistical association between thousands of DNA variations and a human trait have detected 958 loci across 127 different diseases and traits. However, these ...
    • Burden of disease and benefits of exercise in fixed airway obstruction asthma
      Turner, Sian Elizabeth (2009)
      Background and research questions. The characterization of chronic persistent asthma in an older adult population is not well defined. This is due to the difficulties in separating the diagnosis of asthma from that of ...
    • Characterisation of the central region of the sheep major histocompatibility complex
      Qin, Jinyi (2008)
      The major histocompatibility complex (MHC) is a chromosomal region encoding molecules controlling adaptive immune response in vertebrates. In farm animals, many associations between MHC loci and productivity traits including ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.