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    Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging

    241556_Asad 2016 amended version.pdf (2.556Mb)
    Access Status
    Open access
    Authors
    Asad, Ali Haidar Kasim
    Date
    2016
    Supervisor
    Dr Roger Price
    Dr Suzanne Smith
    Dr Brendan McGann
    Collection
    • Curtin Theses
    Type
    Thesis
    Education Level
    Ph.D.
    Metadata
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    Abstract

    For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics.

    URI
    http://hdl.handle.net/20.500.11937/1132
    Department
    Department of Physics and Astronomy
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