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    Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging

    241556_Asad 2016 amended version.pdf (2.556Mb)
    Access Status
    Open access
    Authors
    Asad, Ali Haidar Kasim
    Date
    2016
    Supervisor
    Dr Roger Price
    Dr Suzanne Smith
    Dr Brendan McGann
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    School
    Department of Physics and Astronomy
    URI
    http://hdl.handle.net/20.500.11937/1132
    Collection
    • Curtin Theses
    Abstract

    For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics.

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