Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging
Access Status
Open access
Authors
Asad, Ali Haidar Kasim
Date
2016Supervisor
Dr Roger Price
Dr Suzanne Smith
Dr Brendan McGann
Collection
Type
Thesis
Education Level
Ph.D.
Metadata
Show full item recordAbstract
For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics.
Department
Department of Physics and Astronomy