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dc.contributor.authorAsad, Ali Haidar Kasim
dc.contributor.supervisorDr Roger Price
dc.contributor.supervisorDr Suzanne Smith
dc.contributor.supervisorDr Brendan McGann
dc.date.accessioned2017-01-30T09:59:20Z
dc.date.available2017-01-30T09:59:20Z
dc.date.created2016-07-20T00:03:54Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/20.500.11937/1132
dc.description.abstract

For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics.

dc.languageen
dc.publisherCurtin University
dc.titleNovel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging
dc.typeThesis
dcterms.educationLevelPhD
curtin.departmentDepartment of Physics and Astronomy
curtin.accessStatusOpen access


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