Hypertensive diseases of pregnancy predict parent-reported difficult temperament in infancy
MetadataShow full item record
Objective: Recent research has linked hypertensive diseases of pregnancy with adverse neurodevelopmentaloutcomes in childhood and adulthood. This study aimed to establish whether such effects areobserved in infancy. Methods: This was a prospective pregnancy cohort study of 2,785 pregnancies withcomplete data on hypertensive diseases of pregnancy. Mothers completed a validated Australian adaptationof the Toddler Temperament Scale when the children were 1 year of age (n 5 2,384). Algorithms were used toclassify children as difficult, slow to warm up, intermediate high, intermediate low, or easy, on the basis oftheir temperament scores. We then grouped difficult and intermediate-high infants together and comparedthem with easy, intermediate-low, and slow-to-warm-up infants. We used a multivariable logistic regressionmodel and adjusted for known biomedical, sociodemographic, and psychological factors from the pre- andpostnatal period that may influence child behavioral development. Results: After adjusting for confounders,mothers who were diagnosed with gestational hypertension (odds ratio [OR], 1.36; 95% confidence interval[CI], 1.06–1.75) or preeclampsia (OR, 2.23; 95% CI, 1.18–4.23) were more likely to report that their infantswere in the difficult or intermediate-high classifications in the first year of life compared with infants born tomothers without gestational hypertension or preeclampsia. Conclusion: These data suggest that the linkbetween maternal hypertensive diseases of pregnancy and child behavioral development begins in the firstyear of life.
Showing items related by title, author, creator and subject.
Early life factors are associated with trajectories of consistent organized sport participation over childhood and adolescence: Longitudinal analysis from the Raine StudyHowie, E.; Ng, Leo; Beales, Darren; McVeigh, Joanne; Straker, Leon (2018)© 2018 Objectives: The purpose of this study was to identify early life factors that were associated with childhood and adolescent organized sport participation trajectories. Design: Participants were in the Raine Study, ...
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsiaThomsen, L.; Mccarthy, N.; Melton, P.; Cadby, G.; Austgulen, R.; Nygård, O.; Johnson, M.; Brennecke, S.; Moses, Eric; Bjørge, L.; Iversen, A. (2016)Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing ...
Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohortThomsen, L.; Melton, P.; Tollaksen, K.; Lyslo, I.; Roten, L.; Odland, M.; Strand, K.; Nygard, O.; Sun, C.; Iversen, A.; Austgulen, R.; Moses, Eric; Bjørge, L. (2015)Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for ...