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    Characterisation of Australian Staphylococcus aureus isolates of bovine mastitis origin, and development and evaluation of the potential of vaccines for prevention of mastitis using mouse as a model system

    234310_Gogoi Tiwari 2014.pdf (4.878Mb)
    Access Status
    Open access
    Authors
    Gogoi Tiwari, Jully
    Date
    2014
    Supervisor
    Dr Paul Costantino
    Assoc. Prof. T.K. Mukkur
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/1143
    Collection
    • Curtin Theses
    Abstract

    Serological typing was demonstrated to be more reliable than molecular typing for capsular phenotyping of Australian bovine mastitis-associated Staphylococcus aureus isolates. A relationship between strength of biofilm formation, icaA and icaD genes and extent of mammary tissue damage was apparent. Distribution of MSCRAMMs and exotoxins, and potential of anti-IL6 and anti IL6-receptor antibodies on mortality of infected mice was determined. Biofilm-embedded S. aureus vaccine offered better protection against mammary tissue damage than the planktonic vaccine.

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