Characterisation of Australian Staphylococcus aureus isolates of bovine mastitis origin, and development and evaluation of the potential of vaccines for prevention of mastitis using mouse as a model system

dc.contributor.author	Gogoi Tiwari, Jully
dc.contributor.supervisor	Dr Paul Costantino
dc.contributor.supervisor	Assoc. Prof. T.K. Mukkur
dc.date.accessioned	2017-01-30T09:59:30Z
dc.date.available	2017-01-30T09:59:30Z
dc.date.created	2015-12-04T03:53:43Z
dc.date.issued	2014
dc.identifier.uri	http://hdl.handle.net/20.500.11937/1143
dc.description.abstract	Serological typing was demonstrated to be more reliable than molecular typing for capsular phenotyping of Australian bovine mastitis-associated Staphylococcus aureus isolates. A relationship between strength of biofilm formation, icaA and icaD genes and extent of mammary tissue damage was apparent. Distribution of MSCRAMMs and exotoxins, and potential of anti-IL6 and anti IL6-receptor antibodies on mortality of infected mice was determined. Biofilm-embedded S. aureus vaccine offered better protection against mammary tissue damage than the planktonic vaccine.
dc.language	en
dc.publisher	Curtin University
dc.title	Characterisation of Australian Staphylococcus aureus isolates of bovine mastitis origin, and development and evaluation of the potential of vaccines for prevention of mastitis using mouse as a model system
dc.type	Thesis
dcterms.educationLevel	PhD
curtin.department	School of Biomedical Sciences
curtin.accessStatus	Open access