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    Blood pressure is a major risk factor for renal death: An analysis of 560 352 participants from the asia-pacific region

    Access Status
    Open access via publisher
    Authors
    O'Seaghdha, C.
    Perkovic, V.
    Lam, T.
    McGinn, S.
    Barzi, F.
    Gu, D.
    Cass, A.
    Suh, I.
    Muntner, P.
    Giles, G.
    Ueshima, H.
    Woodward, M.
    Huxley, Rachel
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    O'Seaghdha, C. and Perkovic, V. and Lam, T. and McGinn, S. and Barzi, F. and Gu, D. and Cass, A. et al. 2009. Blood pressure is a major risk factor for renal death: An analysis of 560 352 participants from the asia-pacific region. Hypertension. 54 (3): pp. 509-515.
    Source Title
    Hypertension
    DOI
    10.1161/HYPERTENSIONAHA.108.128413
    ISSN
    0194-911X
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/11624
    Collection
    • Curtin Research Publications
    Abstract

    Chronic kidney disease is a major worldwide public health problem that causes substantial morbidity and mortality. Studies from the Asia-Pacific region have reported some of the highest chronic kidney disease prevalence rates in the world, but access to dialysis is limited in many countries, making it imperative to identify high-risk individuals. We performed a participant-level data overview of prospective studies conducted in the Asia-Pacific region to quantify the magnitude and direction of the associations between putative risk factors and renal death. Age- and sex-adjusted Cox proportional hazards models were applied to pooled data from 35 studies to calculate hazard ratios (95% CIs) for renal death associated with a standardized change in risk factors. Among 560 352 participants followed for a median of 6.8 years, a total of 420 renal deaths were observed. Continuous and positive associations among systolic blood pressure, diastolic blood pressure, fasting blood glucose, and total cholesterol levels with renal death were observed, as well as a continuous but inverse association with high-density lipoprotein cholesterol. Systolic blood pressure was the strongest risk factor for renal death with each SD increase in systolic blood pressure (19 mm Hg) associated with >80% higher risk (hazard ratio: 1.84; 95% CI: 1.60 to 2.12). Neither cigarette smoking nor excess weight was related to the risk of renal death (P>0.10). The results were similar for cohorts in Asia and Australia. These results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia. © 2009 American Heart Association, Inc.

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