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dc.contributor.authorCzernichow, S.
dc.contributor.authorVergnaud, A.
dc.contributor.authorGalan, P.
dc.contributor.authorArnaud, J.
dc.contributor.authorFavier, A.
dc.contributor.authorFaure, H.
dc.contributor.authorHuxley, Rachel
dc.contributor.authorHercberg, S.
dc.contributor.authorAhluwalia, N.
dc.identifier.citationCzernichow, S. and Vergnaud, A. and Galan, P. and Arnaud, J. and Favier, A. and Faure, H. and Huxley, R. et al. 2009. Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults. American Journal of Clinical Nutrition. 90 (2): pp. 329-335.

Background: Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS. Objective: The objective was to examine the effect of antioxidant supplementation for 7.5 y on the incidence of MetS and the epidemiologic association between baseline serum antioxidant concentrations and the prospective risk of MetS. Design: Adults (n = 5220) participating in the SUpplementation en VItamines et Minéraux AntioXydants (SU.VI.MAX) primary prevention trial were randomly assigned to receive a supplement containing a combination of antioxidants (vitamins C and E, ß-carotene, zinc, and selenium) at nutritional doses or a placebo. Subjects were free of MetS at baseline and were followed for 7.5 y. Results: Antioxidant supplementation for 7.5 y did not affect the risk of MetS. Baseline serum antioxidant concentrations of ß-carotene and vitamin C, however, were negatively associated with the risk of MetS; the adjusted odds ratios (and 95% CIs) for the highest compared with the lowest tertile were 0.34 (0.21, 0.53; P for trend = 0.0002) and 0.53 (0.35, 0.80; P for trend = 0.01), respectively. Baseline serum zinc concentrations were positively associated with the risk of developing MetS; the adjusted odds ratio (and 95% CI) for the highest compared with the lowest tertile was 1.81 (1.20, 2.72; P for trend = 0.01). Conclusions: The experimental finding of no beneficial effects of antioxidant supplementation in a generally well-nourished population is consistent with recent reports of a lack of efficacy of antioxidant supplements. However, the relations observed between the risk of MetS and baseline serum antioxidant concentrations, which probably reflect associations with overall dietary patterns, do support the current recommendations to consume antioxidant-rich foods. This trial was registered at as NCT00272428. © 2009 American Society for Nutrition.

dc.publisherAmerican Society for Nutrition
dc.titleEffects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
dc.typeJournal Article
dcterms.source.titleAmerican Journal of Clinical Nutrition
curtin.departmentSchool of Public Health
curtin.accessStatusOpen access via publisher

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