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    Models of Alzheimer’s Disease

    Access Status
    Fulltext not available
    Authors
    Chen, M.
    Kretzschmar, D.
    Verdile, Giuseppe
    Lardelli, M.
    Date
    2014
    Type
    Book Chapter
    
    Metadata
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    Citation
    Chen, M. and Kretzschmar, D. and Verdile, G. and Lardelli, M. 2014. Models of Alzheimer’s Disease. In Animal Models for the Study of Human Disease, ed. P. Michael Conn, 595-632. US: Elsevier.
    Source Title
    Animal Models for the Study of Human Disease
    ISBN
    978-0-12-415894-8
    URI
    http://hdl.handle.net/20.500.11937/11703
    Collection
    • Curtin Research Publications
    Abstract

    Alzheimer’s disease (AD) is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research, there is still widespread debate about its cause(s), and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist, and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease, but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of AD. In this chapter, we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease, but progress in understanding and finding preventative and ameliorative treatments for AD is hindered by the lack of a convincing hypothesis for the cause of this complex condition.

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