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    Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice.

    10970_Redwood A 1997.pdf (10.76Mb)
    Access Status
    Open access
    Authors
    Redwood, Alec J.
    Date
    1997
    Supervisor
    Associate Professor Ian Lee
    Associate Professor John Warmington
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/1182
    Collection
    • Curtin Theses
    Abstract

    Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in infected mice is matched by differences in tissue responses to infection.To determine if cytokine mRNA expression patterns during secondary systemic candidiasis, are different to those during primary systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during secondary systemic candidiasis.

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