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dc.contributor.authorRedwood, Alec J.
dc.contributor.supervisorAssociate Professor Ian Lee
dc.contributor.supervisorAssociate Professor John Warmington
dc.date.accessioned2017-01-30T09:59:58Z
dc.date.available2017-01-30T09:59:58Z
dc.date.created2008-05-14T04:36:42Z
dc.date.issued1997
dc.identifier.urihttp://hdl.handle.net/20.500.11937/1182
dc.description.abstract

Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in infected mice is matched by differences in tissue responses to infection.To determine if cytokine mRNA expression patterns during secondary systemic candidiasis, are different to those during primary systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during secondary systemic candidiasis.

dc.languageen
dc.publisherCurtin University
dc.subjectcytokines
dc.subjectimmune response
dc.subjectCandida albicans
dc.titleCytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice.
dc.typeThesis
dcterms.educationLevelPhD
curtin.thesisTypeTraditional thesis
curtin.departmentSchool of Biomedical Sciences
curtin.identifier.adtidadt-WCU20020729.110134
curtin.accessStatusOpen access


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