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    Body mass index in relation to ovarian cancer survival

    Access Status
    Fulltext not available
    Authors
    Zhang, Min
    Lee, Andy
    Binns, Colin
    Xie, Z.
    Date
    2005
    Type
    Journal Article
    
    Metadata
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    Citation
    Zhang, Min and Lee, Andy and Binns, Colin and Xie, Zing. 2005. Body mass index in relation to ovarian cancer survival. Cancer Epidemiology, Biomarkers & Prevention 14 (5): 1307-1310.
    Source Title
    Cancer Epidemiology, Biomarkers & Prevention
    DOI
    10.1158/1055-9965.EPI-04-0519
    Faculty
    School of Public Health
    Division of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/12513
    Collection
    • Curtin Research Publications
    Abstract

    Evidence for an association between indicators of adiposity and survival after ovarian cancer has been inconsistent. A prospective cohort study was conducted in China to examine the relationship between ovarian cancer survival and body mass index (BMI). From the 214 patients recruited in 1999 to 2000 with histopathologically confirmed invasive epithelial ovarian cancer, 207 patients or their close relatives (96.7% of cases) were traced and followed to 2003. Deaths were recorded and Cox proportional hazards regression was used to obtain hazard ratios (HR) and 95% confidence intervals (95% CI) from multivariate models. Reduced survival was observed among patients with BMI 25 kg/m2 at 5 years before diagnosis (P = 0.001). There were 98 (59.8%) of 164 patients with BMI <25 kg/m2 survived to the time of interview compared with only 15 women (34.9%) among the 43 patients whose BMI was 25 kg/m2. The HRs significantly increased with higher BMI at 5 years before diagnosis but not at diagnosis nor at age 21 years. The adjusted HR was 2.33 (95% CI, 1.12-4.87) for BMI of 25 versus <20 kg/m2, with a significant dose-response relationship. The HR was 3.31 (95% CI, 1.26-8.73) among patients who had been overweight or obese at age 21 years, but a linear dose-response was not found. We conclude that premorbid BMI may have independent prognostic significance in ovarian cancer.

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