Body mass index in relation to ovarian cancer survival
MetadataShow full item record
Evidence for an association between indicators of adiposity and survival after ovarian cancer has been inconsistent. A prospective cohort study was conducted in China to examine the relationship between ovarian cancer survival and body mass index (BMI). From the 214 patients recruited in 1999 to 2000 with histopathologically confirmed invasive epithelial ovarian cancer, 207 patients or their close relatives (96.7% of cases) were traced and followed to 2003. Deaths were recorded and Cox proportional hazards regression was used to obtain hazard ratios (HR) and 95% confidence intervals (95% CI) from multivariate models. Reduced survival was observed among patients with BMI 25 kg/m2 at 5 years before diagnosis (P = 0.001). There were 98 (59.8%) of 164 patients with BMI <25 kg/m2 survived to the time of interview compared with only 15 women (34.9%) among the 43 patients whose BMI was 25 kg/m2. The HRs significantly increased with higher BMI at 5 years before diagnosis but not at diagnosis nor at age 21 years. The adjusted HR was 2.33 (95% CI, 1.12-4.87) for BMI of 25 versus <20 kg/m2, with a significant dose-response relationship. The HR was 3.31 (95% CI, 1.26-8.73) among patients who had been overweight or obese at age 21 years, but a linear dose-response was not found. We conclude that premorbid BMI may have independent prognostic significance in ovarian cancer.
Showing items related by title, author, creator and subject.
Mechanisms underlying acquired platinum resistance in high grade serous ovarian cancer - a mini reviewBinju, M.; Padilla, M.; Singomat, T.; Kaur, Pritinder; Suryo Rahmanto, Y.; Cohen, P.; Yu, Yu (2019)© 2018 Elsevier B.V. Background: Advanced epithelial ovarian cancer is one of the hardest human malignancies to treat. Standard treatment involves cytoreductive surgery and platinum-based chemotherapy, however, median ...
Pericytes promote malignant ovarian cancer progression in mice and predict poor prognosis in serous ovarian cancer patientsSinha, D.; Chong, L.; George, J.; Schlüter, H.; Mönchgesang, S.; Mills, S.; Li, J.; Parish, C.; Bowtell, D.; Kaur, Pritinder (2016)Purpose: The aim of this study was to investigate the role of pericytes in regulating malignant ovarian cancer progression. Experimental Design: The pericyte mRNA signature was used to interrogate ovarian cancer patient ...
Zhang, Min; Binns, Colin; Lee, Andy (2002)To investigate whether tea consumption has an etiological associationwith ovarian cancer, a case-control study was conducted in China during 1999–2000. The cases were 254 patients with histologically confirmed epithelial ...