Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery
MetadataShow full item record
In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposite (NH2-SiO2@LDH) via electrostatic interactions and condensation of (3-aminopropyl)triethoxysilane (APTES). This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA (siRNA) into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiO2@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery.
Showing items related by title, author, creator and subject.
Bhattacharyya, D.; Dong, Yu (2008)In recent years, the usage of polymer nanocomposites has been increasing rapidly. However, although their functional properties are superior, often the relevant mechanical properties do not give sufficient consistency to ...
2D porous graphitic C3N4 nanosheets/Ag 3PO4 nanocomposites for enhanced visible-light photocatalytic degradation of 4-chlorophenolRen, Y.; Zhao, Q.; Li, Xin Yong; Xiong, W.; Tade, Moses; Liu, Lihong (2014)A novel visible-light-activated photocatalyst consisting of porous graphitic C3N4 nanosheets and Ag3PO4 nanoparticles were synthesized through a tunable in situ deposition method. The morphology and microstructure of the ...
Microstructural design and properties of high performance recycled cellulose fibre reinforced polymer eco-nanocompositesAlamri, Hatem Rashed (2012)In recent years, cellulose fibre-reinforced polymer composites have been gaining a great attention in several engineering applications due to their desirable properties, which include low density, low cost, renewability ...