Target DNA recognition using electrochemical impedance spectroscopy
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Authors
Michaels, P.
Ciampi, Simone
Yean, C.
Gooding, J.
Date
2010Type
Conference Paper
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Michaels, P. and Ciampi, S. and Yean, C. and Gooding, J. 2010. Target DNA recognition using electrochemical impedance spectroscopy, pp. 282-284.
Source Title
ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
ISBN
School
Nanochemistry Research Institute
Collection
Abstract
Electrochemical impedance spectroscopy was used to differentiate between different target DNA sequences without the use of a redox label or application of large bias voltages. This method relies on the formation of a mixed self-assembled monolayer (SAMs) composed of single-stranded DNA and a diluent, mercaptoethanol. Recognition of the DNA analytes was achieved through the significant increase in conductance for the double stranded DNA, as compared to single-stranded DNA. Non-complementary and single base-pair mismatches were also able to be differentiated. © 2010 IEEE.