Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Novel roles for class II Phosphoinositide 3-Kinase C2ß in signalling pathways involved in prostate cancer cell invasion.

    Access Status
    Open access via publisher
    Authors
    Mavrommati, I.
    Cisse, O.
    Falasca, Marco
    Maffucci, T.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mavrommati, I. and Cisse, O. and Falasca, M. and Maffucci, T. 2016. Novel roles for class II Phosphoinositide 3-Kinase C2ß in signalling pathways involved in prostate cancer cell invasion.. Scientific Reports. 6: pp. 23277-23277.
    Source Title
    Scientific Reports
    DOI
    10.1038/srep23277
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/13051
    Collection
    • Curtin Research Publications
    Abstract

    Phosphoinositide 3-kinases (PI3Ks) regulate several cellular functions such as proliferation, growth, survival and migration. The eight PI3K isoforms are grouped into three classes and the three enzymes belonging to the class II subfamily (PI3K-C2a, ß and ?) are the least investigated amongst all PI3Ks. Interest on these isoforms has been recently fuelled by the identification of specific physiological roles for class II PI3Ks and by accumulating evidence indicating their involvement in human diseases. While it is now established that these isoforms can regulate distinct cellular functions compared to other PI3Ks, there is still a limited understanding of the signalling pathways that can be specifically regulated by class II PI3Ks. Here we show that PI3K-C2ß regulates mitogen-activated protein kinase kinase (MEK1/2) and extracellular signal-regulated kinase (ERK1/2) activation in prostate cancer (PCa) cells. We further demonstrate that MEK/ERK and PI3K-C2ß are required for PCa cell invasion but not proliferation. In addition we show that PI3K-C2ß but not MEK/ERK regulates PCa cell migration as well as expression of the transcription factor Slug. These data identify novel signalling pathways specifically regulated by PI3K-C2ß and they further identify this enzyme as a key regulator of PCa cell migration and invasion.

    Related items

    Showing items related by title, author, creator and subject.

    • PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
      Dituri, F.; Mazzocca, A.; Lupo, L.; Edling, C.; Azzariti, A.; Antonaci, S.; Falasca, Marco; Giannelli, G. (2012)
      Alterations of the cell cycle checkpoint frequently occur during hepatocarcinogenesis. Dysregulation of the phosphatidylinositol-3-kinases (PI3K) signaling pathway is believed to exert a potential oncogenic effect in ...
    • 3-phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer
      Fyffe, C.; Falasca, Marco (2013)
      It should be noted that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is a protein encoded by the PDPK1 gene, which plays a key role in the signaling pathways activated by several growth factors and hormones. PDK1 ...
    • Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1
      Yu, Yu; Richardson, D. (2011)
      The role of signaling pathways in the regulation of cellular iron metabolism is becoming increasingly recognized. Iron chelation is used for the treatment of iron overload but also as a potential strategy for cancer ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.