Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: baseline data from a DIAN cohort subset
MetadataShow full item record
Introduction: This study examines platelet amyloid precursor protein (APP) isoform ratios of 120KDa to 110KDa (APPr) between mutation carriers (MC) carrying a mutation for autosomal dominant Alzheimer's disease (ADAD) and non-carriers (NC). Two previous studies reported no significant difference in APPr between ADAD MC and NC, which may have been due to the small sample size in both studies. The current study examines APPr in MC versus NC in a larger sample. In addition, it investigated whether APPr correlate with neuroimaging data, neuropsychological data and cerebrospinal fluid biomarkers in a cohort subset derived from the Dominantly Inherited Alzheimer Network (DIAN) study. METHODS: APPr were quantified by western blotting. Fifteen MC (symptomatic and asymptomatic) were compared against twelve NC using univariate general linear model. All participants underwent neuroimaging and neuropsychological testing which were correlated with APPr using Pearson's correlation coefficient (r). RESULTS: APPr were lower in MC compared to NC (p=0.003) while Mini-Mental State Examination (MMSE) scores were not significantly different (p>0.1). Furthermore, APPr inversely correlated with amyloid imaging in the Caudate Nucleus (r=-0.505; p<0.05) and Precuneus (r=-0.510; p<0.05). CONCLUSION: APPr are lower in ADAD MC compared to NC, and inversely correlated with brain amyloid load prior to significant differences in cognitive health. However, the use of APPr as a biomarker needs to be explored further.
Showing items related by title, author, creator and subject.
Nie, Katherine Su (2007)Numerous popular business publications and academic literature have highlighted that the Chinese cultural phenomenon of guanxi has made noticeable impacts on the economic efficiency in China’s economic transition. Despite ...
Determination of residual gas saturation and gas-water relative permeability in water-driven gas reservoirs.Mulyadi, Henny (2002)The research on Determination of Residual Gas Saturation and Gas-Water Relative Permeability in Water-Driven Gas Reservoirs is divided into four stages: literature research, core-flooding experiments, development and ...
Anglim, Jeromy; Dunlop, Patrick ; Wee, Serena; Horwood, Sharon; Wood, Joshua K; Marty, Andrew (2022)This study provides a comprehensive assessment of the associations of personality and intelligence. It presents a meta-analysis (N = 162,636, k = 272) of domain, facet, and item-level correlations between personality and ...