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    Obstructive sleep apnoea: From pathogenesis to treatment: Current controversies and future directions

    Access Status
    Open access via publisher
    Authors
    Eastwood, Peter
    Malhotra, A.
    Palmer, L.
    Kezirian, E.
    Horner, R.
    Ip, M.
    Thurnheer, R.
    Antic, N.
    Hillman, D.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Eastwood, P. and Malhotra, A. and Palmer, L. and Kezirian, E. and Horner, R. and Ip, M. and Thurnheer, R. et al. 2010. Obstructive sleep apnoea: From pathogenesis to treatment: Current controversies and future directions. Respirology. 15 (4): pp. 587-595.
    Source Title
    Respirology
    DOI
    10.1111/j.1440-1843.2009.01699.x
    ISSN
    1323-7799
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/13408
    Collection
    • Curtin Research Publications
    Abstract

    Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets. © 2010 Asian Pacific Society of Respirology.

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