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    Plasma retinol, carotene and vitamin E concentrations and lung function in a crocidolite-exposed cohort from Wittenoom, Western Australia: a cohort study

    Access Status
    Fulltext not available
    Authors
    Alfonso, Helman
    Fritschi, L.
    De Klerk, N.
    Ambrosini, G.
    Beilby, J.
    Olsen, N.
    Musk, A.
    Date
    2005
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Alfonso, Helman and Fritschi, Lin and De Klerk, Nicholas H. and Ambrosini, Gina and Beilby, John and Olsen, Nola and Musk, A. William. 2005. Plasma retinol, carotene and vitamin E concentrations and lung function in a crocidolite-exposed cohort from Wittenoom, Western Australia: a cohort study. Nutrition Journal 4.
    Source Title
    Nutrition Journal
    Additional URLs
    http://www.nutritionj.com/articles/browse.asp?date=5-2005
    Faculty
    School of Public Health
    Division of Health Sciences
    Remarks

    See above link for open access to the full text of this document.

    URI
    http://hdl.handle.net/20.500.11937/13450
    Collection
    • Curtin Research Publications
    Abstract

    BackgroundIncreased rates of death from asbestos related diseases have been reported for people previously employed in the mining and milling operations at Wittenoom (Western Australia), and people who lived in the nearby town, where they were environmentally exposed to crocidolite.MethodsAnnual measurements of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) and plasma concentrations of retinol, carotene and vitamin E have been made since 1992. Mixed effects models were used to examine the associations between lung function and the plasma vitamin levels of retinol, carotene and vitamin E.ResultsAfter adjusting for potential confounders, higher plasma retinol and carotene concentrations were significantly associated with higher levels of lung function at entry into the study, while vitamin E concentrations were associated with lower entry lung function. Retinol was associated with a less steep decline of lung function over time, while carotene concentrations were associated with an increased decline of lung function over time and vitamin E levels were not associated with changes of lung function over time.ConclusionThese results support a beneficial relationship between plasma concentrations of retinol on the levels and rates of change of lung function, while showing no such consistent beneficial effect for plasma levels of beta-carotene or vitamin E.

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    • Plasma retinol and total carotenes and fracture risk after long-term supplementation with high doses of retinol
      Ambrosini, G.; Alfonso, Helman; Reid, Alison; Mackerras, D.; Bremner, A.; Beilby, J.; Olsen, N.; Musk, A.; de Klerk, N. (2014)
      Observational studies suggest that moderate intakes of retinol and increased circulating retinol levels may increase fracture risk. Easy access to supplements, combined with an aging population, makes this a potentially ...
    • Plasma concentrations of retinol, carotene, and vitamin E and mortality in subjects with asbestosis in a cohort exposed to crocidolite in Wittenoom, Western Australia
      Alfonso, Helman; Fritschi, L.; De Klerk, N.; Ambrosini, G.; Beilby, J.; Olsen, N.; Musk, A. (2005)
      OBJECTIVE: We sought to examine the relationships between plasma concentrations of retinol, carotene, and vitamin E and mortality associated with asbestosis in people previously exposed to crocidolite. METHODS: Cox ...
    • No dose-dependent increase in fracture risk after long-term exposure to high doses of retinol or beta-carotene
      Ambrosini, G.; Bremner, A.; Reid, Alison; Mackerras, D.; Alfonso, Helman; Olsen, N.; Musk, A.; De Klerk, N. (2013)
      Summary: Uncertainty remains over whether or not high intakes of retinol or vitamin A consumed through food or supplements may increase fracture risk. This intervention study found no increase in fracture risk among 2,322 ...
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