Replicating methicillin resistance?

Ramsay, Joshua

doi:10.1038/nsmb.3303

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Authors

Ramsay, Joshua

Date

2016

Type

Journal Article

Metadata

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Citation

Ramsay, J. 2016. Replicating methicillin resistance? Nature Structural and Molecular Biology. 23 (10): pp. 874-875.

Source Title

Nature Structural and Molecular Biology

DOI

10.1038/nsmb.3303

ISSN

1545-9993

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/13746

Collection

Curtin Research Publications

Abstract

Methicillin resistance in the clinically important bacterium Staphylococcus aureus (MRSA) has evolved in multiple S. aureus lineages through acquisition of chromosomally integrating mobile genetic elements named SCCmec. Now Rice and colleagues show that the conserved SCCmec cch gene encodes an active DNA helicase, thus suggesting that extrachromosomal replication is part of the enigmatic SCCmec horizontal-transfer mechanism.