Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Theses
    • View Item
    • espace Home
    • espace
    • Curtin Theses
    • View Item

    Role of extracellular matrix in muscle repair and regeneration

    213690_Chaturvedi 2015.pdf (4.698Mb)
    Access Status
    Open access
    Authors
    Chaturvedi, Vishal
    Date
    2014
    Supervisor
    Dr Danielle Dye
    Prof. Miranda Grounds
    Prof. Deirdre Coombe
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Biomedical Sciences, Curtin Health Innovation Research Institute (CHIRI) Biosciences Research Precinct
    URI
    http://hdl.handle.net/20.500.11937/1381
    Collection
    • Curtin Theses
    Abstract

    Extracellular matrices (ECMs) play important structural and mechanical roles in muscle tissue. They are also critical for normal muscle homeostasis, but it is poorly understood how individual matrix proteins, or the mix of ECM proteins found in vivo affect myoblast behaviour. Aspects of this question have been examined in this thesis using both matrices from skeletal muscle and artificial scaffolds prepared from silk proteins. The ability of these surfaces to support myoblast proliferation and differentiation was examined using a murine myoblast cell line and primary human skeletal muscle myoblasts.

    Related items

    Showing items related by title, author, creator and subject.

    • Interactions between skeletal muscle myoblasts and their extracellular matrix revealed by a serum free culture system
      Chaturvedi, Vishal; Dye, Danielle; Kinnear, Bev; Van Kuppevelt, T.; Grounds, M.; Coombe, Deidre (2015)
      Decellularisation of skeletal muscle provides a system to study the interactions of myoblasts with muscle extracellular matrix (ECM). This study describes the efficient decellularisation of quadriceps muscle with the ...
    • Role of extracellular matrix in muscle repair and regeneration
      Chaturvedi, Vishal (2014)
      Extracellular matrices (ECMs) play important structural and mechanical roles in muscle tissue. They are also critical for normal muscle homeostasis, but it is poorly understood how individual matrix proteins, or the mix ...
    • Silk fibroin scaffolds with muscle-like elasticity support in vitro differentiation of human skeletal muscle cells
      Chaturvedi, V.; Naskar, D.; Kinnear, B.; Grenik, E.; Dye, Danielle; Grounds, M.; Kundu, S.; Coombe, D. (2016)
      Human adult skeletal muscle has a limited ability to regenerate after injury and therapeutic options for volumetric muscle loss are few. Technologies to enhance regeneration of tissues generally rely upon bioscaffolds to ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.