The cancer genome atlas pan-cancer analysis project

Weinstein, J.; Collisson, E.; Mills, G.; Shaw, K.; Ozenberger, B.; Ellrott, K.; Sander, C.; Stuart, J.; Chang, K.; Creighton, C.; Davis, C.; Donehower, L.; Drummond, J.; Wheeler, D.; Ally, A.; Balasundaram, M.; Birol, I.; Butterfield, Y.; Chu, A.; Chuah, E.; Chun, H.; Dhalla, N.; Guin, R.; Hirst, M.; Hirst, C.; Holt, R.; Jones, S.; Lee, D.; Li, H.; Marra, M.; Mayo, M.; Moore, R.; Mungall, A.; Robertson, A.; Schein, J.; Sipahimalani, P.; Tam, A.; Thiessen, N.; Varhol, Richard; Beroukhim, R.; Bhatt, A.; Brooks, A.; Cherniack, A.; Freeman, S.; Gabriel, S.; Helman, E.; Jung, J.; Meyerson, M.; Ojesina, A.; Pedamallu, C.; Saksena, G.; Schumacher, S.; Tabak, B.; Zack, T.; Lander, E.; Bristow, C.; Hadjipanayis, A.; Haseley, P.; Kucherlapati, R.; Lee, S.; Lee, E.; Luquette, L.; Mahadeshwar, H.; Pantazi, A.; Parfenov, M.; Park, P.; Protopopov, A.; Ren, X.; Santoso, N.; Seidman, J.; Seth, S.; Song, X.; Tang, J.; Xi, R.; Xu, A.; Yang, L.; Zeng, D.; Auman, J.; Balu, S.; Buda, E.

doi:10.1038/ng.2764

Access Status

Open access via publisher

Authors

Weinstein, J.

Collisson, E.

Mills, G.

Shaw, K.

Ozenberger, B.

Ellrott, K.

Sander, C.

Stuart, J.

Chang, K.

Creighton, C.

Davis, C.

Donehower, L.

Drummond, J.

Wheeler, D.

Ally, A.

Balasundaram, M.

Birol, I.

Butterfield, Y.

Chu, A.

Chuah, E.

Chun, H.

Dhalla, N.

Guin, R.

Hirst, M.

Hirst, C.

Holt, R.

Jones, S.

Lee, D.

Li, H.

Marra, M.

Mayo, M.

Moore, R.

Mungall, A.

Robertson, A.

Schein, J.

Sipahimalani, P.

Tam, A.

Thiessen, N.

Varhol, Richard

Beroukhim, R.

Bhatt, A.

Brooks, A.

Cherniack, A.

Freeman, S.

Gabriel, S.

Helman, E.

Jung, J.

Meyerson, M.

Ojesina, A.

Pedamallu, C.

Saksena, G.

Schumacher, S.

Tabak, B.

Zack, T.

Lander, E.

Bristow, C.

Hadjipanayis, A.

Haseley, P.

Kucherlapati, R.

Lee, S.

Lee, E.

Luquette, L.

Mahadeshwar, H.

Pantazi, A.

Parfenov, M.

Park, P.

Protopopov, A.

Ren, X.

Santoso, N.

Seidman, J.

Seth, S.

Song, X.

Tang, J.

Xi, R.

Xu, A.

Yang, L.

Zeng, D.

Auman, J.

Balu, S.

Buda, E.

Date

2013

Type

Journal Article

Metadata

Show full item record

Citation

Weinstein, J. and Collisson, E. and Mills, G. and Shaw, K. and Ozenberger, B. and Ellrott, K. and Sander, C. et al. 2013. The cancer genome atlas pan-cancer analysis project. Nature Genetics. 45 (10): pp. 1113-1120.

Source Title

Nature Genetics

DOI

10.1038/ng.2764

ISSN

1061-4036

School

Department of Health Policy and Management

URI

http://hdl.handle.net/20.500.11937/13835

Collection

Curtin Research Publications

Abstract

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.