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dc.contributor.authorRuwanpathirana, T.
dc.contributor.authorOwen, A.
dc.contributor.authorRenzaho, A.
dc.contributor.authorZomer, E.
dc.contributor.authorGambhir, M.
dc.contributor.authorReid, Christopher
dc.identifier.citationRuwanpathirana, T. and Owen, A. and Renzaho, A. and Zomer, E. and Gambhir, M. and Reid, C. 2015. Can oral vitamin D prevent the cardiovascular diseases among migrants in Australia? Provider perspective using Markov modelling. Clinical and Experimental Pharmacology and Physiology. 42 (6): pp. 596-601.

The study was designed to model the effectiveness and cost effectiveness of oral Vitamin D supplementation as a primary prevention strategy for cardiovascular disease among a migrant population in Australia. It was carried out in the Community Health Service, Kensington, Melbourne. Best-case scenario analysis using a Markov model was employed to look at the health care providers’ perspective. Adult migrants who were vitamin D deficient and free from cardiovascular disease visiting the medical centre at least once during the period from 1 January 2010 to 31 December 2012 were included in the study. The blood pressure-lowering effect of vitamin D was taken from a published meta-analysis and applied in the Framingham 10 year cardiovascular risk algorithm (with and without oral vitamin D supplements) to generate the probabilities of cardiovascular events. A Markov decision model was used to estimate the provider costs associated with the events and treatments. Uncertainties were derived by Monte Carlo simulation. Vitamin D oral supplementation (1000 IU/day) for 10 years could potentially prevent 31 (interquartile range (IQR) 26 to 37) non-fatal and 11 (IQR 10 to 15) fatal cardiovascular events in a migrant population of 10 000 assuming 100% compliance. The provider perspective incremental cost effectiveness per year of life saved was AU$3,992 (IQR 583 to 8558). This study suggests subsidised supplementation of oral vitamin D may be a cost effective intervention to reduce non-fatal and fatal cardiovascular outcomes in high-risk migrant populations.

dc.publisherWiley-Blackwell Publishing Asia
dc.subjectframingham risk score
dc.subjectcardiovascular disease
dc.subjectvitamin D deficiency
dc.subjectmarkov models
dc.titleCan oral vitamin D prevent the cardiovascular diseases among migrants in Australia? Provider perspective using Markov modelling
dc.typeJournal Article
dcterms.source.titleClinical and Experimental Pharmacology and Physiology
curtin.accessStatusFulltext not available

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