Polymer-gold nanohybrids with potential use in bimodal MRI/CT: Enhancing the relaxometric properties of Gd(III) complexes

Beija, M. and Li, Y. and Duong, H. and Laurent, S. and Elst, L. and Muller, R. and Lowe, A. et al. 2012. Polymer-gold nanohybrids with potential use in bimodal MRI/CT: Enhancing the relaxometric properties of Gd(III) complexes. Journal of Materials Chemistry. 22 (40): pp. 21382-21386.

Source Title

Journal of Materials Chemistry

DOI

10.1039/c2jm34999j

ISSN

0959-9428

School

Nanochemistry Research Institute

URI

http://hdl.handle.net/20.500.11937/14095

Collection

Curtin Research Publications

Abstract

We present a new synthetic strategy to produce Gd(III)-decorated gold nanoparticles (AuNPs) for potential use as bimodal contrast agents (CA) for computed X-ray tomography (CT) and magnetic resonance imaging (MRI). The hybrid AuNPs exhibit high molar relaxivities (>12 000 mM−1 s−1 per particle), indicative of highly efficient CT/MRI CAs.