Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Use of serum lactate levels to predict survival for patients with out-of-hospital cardiac arrest: A cohort study

    239108_239108.pdf (412.6Kb)
    Access Status
    Open access
    Authors
    Williams, Teresa
    Martin, R.
    Celenza, A.
    Bremner, A.
    Fatovich, D.
    Krause, J.
    Arena, S.
    Finn, Judith
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Williams, T. and Martin, R. and Celenza, A. and Bremner, A. and Fatovich, D. and Krause, J. and Arena, S. et al. 2016. Use of serum lactate levels to predict survival for patients with out-of-hospital cardiac arrest: A cohort study. Emergency Medicine Australasia. 28 (2): pp. 171-178.
    Source Title
    EMA - Emergency Medicine Australasia
    DOI
    10.1111/1742-6723.12560
    ISSN
    1742-6731
    School
    School of Nursing and Midwifery
    Remarks

    This is the peer reviewed version of the following article: Williams, T. and Martin, R. and Celenza, A. and Bremner, A. and Fatovich, D. and Krause, J. and Arena, S. et al. 2016. Use of serum lactate levels to predict survival for patients with out-of-hospital cardiac arrest: A cohort study. Emergency Medicine Australasia. 28 (2): pp. 171-178., which has been published in final form at http://doi.org/10.1111/1742-6723.12560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms

    URI
    http://hdl.handle.net/20.500.11937/14429
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: We examined the association of serum lactate levels and early lactate clearance with survival to hospital discharge for patients suffering an out-of-hospital cardiac arrest (OHCA). Methods: A retrospective cohort analysis was performed of patients with OHCA transported by ambulance to two adult tertiary hospitals in Perth, Western Australia. Exclusion criteria were traumatic cardiac arrest, return of spontaneous circulation prior to the arrival of the ambulance, age less than 18 years and no serum lactate levels recorded. Serum lactate levels recorded for up to 48h post-arrest were obtained from the hospital clinical information system, and lactate clearance over 48h was calculated. Descriptive and logistic regression analyses were conducted. Results: There were 518 patients with lactate values, of whom 126 (24.3%) survived to hospital discharge. Survivors and non-survivors had different mean initial lactate levels (mean±SD 6.9±4.7 and 12.2±5.5mmol/L, respectively; P<0.001). Lactate clearance was higher in survivors. Lactate levels for non-survivors did not decrease below 2mmol/L until at least 30h after the ambulance call. Conclusion: In OHCA patients who had serum lactate levels measured, both lower initial serum lactate and early lactate clearance in the first 48h following OHCA were associated with increased likelihood of survival. However, the use of lactate in isolation as a predictor of survival or neurological outcome is not recommended. Prospective studies that minimise selection bias are required to determine the clinical utility of serum lactate levels in OHCA patients. © 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

    Related items

    Showing items related by title, author, creator and subject.

    • Warning symptoms preceding out-of-hospital cardiac arrest: Do patient delays matter?
      Nehme, Z.; Bernard, S.; Andrew, E.; Cameron, P.; Bray, Janet; Smith, K. (2018)
      Background: Although increasing patient delays between symptom onset and activation of emergency medical services (EMS) can lead to poorer outcomes following acute myocardial infarction, its effect in out-of-hospital ...
    • Relative long-term survival in out-of-hospital cardiac arrest: Is it really improving?
      Majewski, David ; Ball, Stephen ; Bailey, P.; Bray, Janet ; Finn, Judith (2020)
      Aim: To describe the long-term survival of out-of-hospital cardiac arrest (OHCA) patients and to determine whether survival is improving in comparison to the general age- and sex-matched population. Methods: We utilised ...
    • Out-of-hospital cardiac arrest outcomes in emergency departments
      Kempster, K.; Howell, S.; Bernard, S.; Smith, K.; Cameron, P.; Finn, Judith ; Stub, D.; Morley, P.; Bray, Janet (2021)
      Background: The emergency department (ED) plays an important role in out-hospital-cardiac arrest (OHCA) management. However, ED outcomes are not widely reported. This study aimed to (1) describe OHCA ED outcomes and reasons ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.