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    Australian Enterococcal Sepsis Outcome Progamme, 2011.

    Access Status
    Fulltext not available
    Authors
    Coombs, Geoffrey
    Pearson, J.
    Le, T.
    Daly, D.
    Robinson, J.
    Gottlieb, T.
    Howden, B.
    Johnson, P.
    Bennett, C.
    Stinear, T.
    Turnidge, J.
    Australian Group on Antimicrobial Resistance
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Coombs, G. and Pearson, J. and Le, T. and Daly, D. and Robinson, J. and Gottlieb, T. and Howden, B. et al. 2014. Australian Enterococcal Sepsis Outcome Progamme, 2011.. Commun Dis Intell Q Rep. 38 (3): pp. E247-E252.
    Source Title
    Commun Dis Intell Q Rep
    ISSN
    1447-4514
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/14568
    Collection
    • Curtin Research Publications
    Abstract

    From 1 January to 31 December 2011, 29 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2011 was to determine the proportion of enterococcal bacteraemia isolates in Australia that are antimicrobial resistant, with particular emphasis on susceptibility to ampicillin and the glycopeptides, and to characterise the molecular epidemiology of the Enterococcus faecalis and E. faecium isolates. Of the 1,079 unique episodes of bacteraemia investigated, 95.8% were caused by either E. faecalis (61.0%) or E. faecium (34.8%). Ampicillin resistance was detected in 90.4% of E. faecium but not detected in E. faecalis. Using Clinical and Laboratory Standards Institute breakpoints (CLSI), vancomycin non-susceptibility was reported in 0.6% and 31.4% of E. faecalis and E. faecium respectively and was predominately due to the acquisition of the vanB operon. Approximately 1 in 6 vanB E. faecium isolates however, had an minimum inhibitory concentration at or below the CLSI vancomycin susceptible breakpoint of = 4 mg/L. Overall, 37% of E. faecium harboured vanA or vanB genes. Although molecular typing identified 126 E. faecalis pulsed-field gel electrophoresis (PFGE) pulsotypes, more than 50% belonged to 2 pulsotypes that were isolated across Australia. E. faecium consisted of 73 PFGE pulsotypes from which 43 multilocus sequence types were identified. Almost 90% of the E. faecium were identified as clonal complex 17 clones, of which approximately half were characterised as sequence type 203, which was isolated Australia-wide. In conclusion, the AESOP 2011 has shown that although polyclonal, enterococcal bacteraemias in Australia are frequently caused by ampicillin-resistant vanB E. faecium.

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    • Molecular Epidemiology of Enterococcal Bacteremia in Australia
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    • Australian Enterococcal Sepsis Outcome Progamme, 2011
      Coombs, Geoffrey; Pearson, J.; Daley, D.; Le, T.; Robinson, J.; Gottlieb, T.; Howden, B.; Johnson, P.; Bennett, C.; Stinear, T.; Turnidge, J. (2014)
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    • Australian Group on Antimicrobial Resistance Australian Enterococcal Sepsis Outcome Programme annual report, 2014
      Coombs, Geoffrey; Daley, D.; Thin Lee, Y.; Pang, S.; Pearson, J.; Robinson, J.; Johnson, P.; Kotsanas, D.; Bell, J.; Turnidge, J. (2016)
      From 1 January to 31 December 2014, 27 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2014 was to determine the proportion of enterococcal ...
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