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    p53-targeted cancer pharmacotherapy: move towards small molecule compounds

    Access Status
    Open access via publisher
    Authors
    Kim, S.
    Dass, Crispin
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Kim, S. and Dass, C. 2011. p53-targeted cancer pharmacotherapy: move towards small molecule compounds. Journal of Pharmacy and Pharmacology. 63: pp. 603-610.
    Source Title
    Journal of Pharmacy and Pharmacology
    DOI
    10.1111/j.2042-7158.2010.01248.x
    ISSN
    0022-3573
    URI
    http://hdl.handle.net/20.500.11937/14671
    Collection
    • Curtin Research Publications
    Abstract

    Objectives For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumour suppressor protein is involved in apoptosis, cell cycle arrest and senescence. A wide range of pharmaceutical drugs and radiotherapy treatments activate this protein and rely on p53 signalling for therapeutic outcome. Promising small molecular weight compounds, some of which are undergoing clinical trials, are discussed in this review. Key findings The spectrum of potential therapeutic approaches trialled for p53 stretch from gene therapy to the more recent development of small molecules capable of activating wild-type p53 or reactivating mutant p53. Summary Our ever-growing knowledge leads us to better understand this protein, from its structure and activities to its potential therapeutic application, firstly for cancer and then for other diseases and maybe even for reversal of ageing.

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