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dc.contributor.authorLawrence, B.
dc.contributor.authorGasson, Natalie
dc.contributor.authorKane, Robert
dc.contributor.authorBucks, R.
dc.contributor.authorLoftus, Andrea
dc.date.accessioned2017-01-30T11:47:04Z
dc.date.available2017-01-30T11:47:04Z
dc.date.created2014-09-05T04:48:05Z
dc.date.issued2014
dc.identifier.citationLawrence, B. and Gasson, N. and Kane, R. and Bucks, R. and Loftus, A. 2014. Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease. PLoS ONE. 9 (7): Article ID e102294.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/14975
dc.identifier.doi10.1371/journal.pone.0102294
dc.description.abstract

This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson’s disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson’s Disease Questionnaire-39 (PDQ-39), and Unified Parkinson’s Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HRQOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.

dc.publisherPublic Library of Science
dc.titleActivities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number7
dcterms.source.startPage1
dcterms.source.endPage5
dcterms.source.issn1932-6203
dcterms.source.titlePLoS ONE
curtin.note

This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by/4.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work

curtin.departmentSchool of Psychology
curtin.accessStatusOpen access


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