Typhoid Fever and Its Association with Environmental Factors in the Dhaka Metropolitan Area of Bangladesh: A Spatial and Time-Series Approach
MetadataShow full item record
This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.
Typhoid fever is a major cause of death worldwide with a major part of the disease burden in developing regions such as the Indian sub-continent. Bangladesh is part of this highly endemic region, yet little is known about the spatial and temporal distribution of the disease at a regional scale. This research used a Geographic Information System to explore, spatially and temporally, the prevalence of typhoid in Dhaka Metropolitan Area (DMA) of Bangladesh over the period 2005–9. This paper provides the first study of the spatio-temporal epidemiology of typhoid for this region. The aims of the study were: (i) to analyse the epidemiology of cases from 2005 to 2009; (ii) to identify spatial patterns of infection based on two spatial hypotheses; and (iii) to determine the hydro-climatological factors associated with typhoid prevalence. Case occurrences data were collected from 11 major hospitals in DMA, geocoded to census tract level, and used in a spatiotemporal analysis with a range of demographic, environmental and meteorological variables. Analyses revealed distinct seasonality as well as age and gender differences, with males and very young children being disproportionately infected. The male-female ratio of typhoid cases was found to be 1.36, and the median age of the cases was 14 years.Typhoid incidence was higher in male population than female (x2 = 5.88, p<0.05). The age-specific incidence rate was highest for the 0–4 years age group (277 cases), followed by the 60+ years age group (51 cases), then there were 45 cases for 15–17 years, 37 cases for 18–34 years, 34 cases for 35–39 years and 11 cases for 10–14 years per 100,000 people. Monsoon months had the highest disease occurrences (44.62%) followed by the pre-monsoon (30.54%) and post-monsoon (24.85%) season. The Student’s t test revealed that there is no significant difference on the occurrence of typhoid between urban and rural environments (p>0.05). A statistically significant inverse association was found between typhoid incidence and distance to major waterbodies. Spatial pattern analysis showed that there was a significant clustering of typhoid distribution in the study area. Moran’s I was highest (0.879; p<0.01) in 2008 and lowest (0.075; p<0.05) in 2009.Incidence rates were found to form three large, multi-centred, spatial clusters with no significant difference between urban and rural rates. Temporally, typhoid incidence was seen to increase with temperature, rainfall and river level at time lags ranging from three to five weeks. For example, for a 0.1 metre rise in river levels, the number of typhoid cases increased by 4.6% (95% CI: 2.4–2.8) above the threshold of 4.0 metres (95% CI: 2.4–4.3). On the other hand, with a 1° C rise in temperature, the number of typhoid cases could increase by 14.2% (95% CI: 4.4–25.0).
Showing items related by title, author, creator and subject.
Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance studyMarks, F.; von Kalckreuth, V.; Aaby, P.; Adu-Sarkodie, Y.; El Tayeb, M.; Ali, Mohammed; Aseffa, A.; Baker, S.; Biggs, H.; Bjerregaard-Andersen, M.; Breiman, R.; Campbell, J.; Cosmas, L.; Crump, J.; Espinoza, L.; Deerin, J.; Dekker, D.; Fields, B.; Gasmelseed, N.; Hertz, J.; Van Minh Hoang, N.; Im, J.; Jaeger, A.; Jeon, H.; Kabore, L.; Keddy, K.; Konings, F.; Krumkamp, R.; Ley, B.; Løfberg, S.; May, J.; Meyer, C.; Mintz, E.; Montgomery, J.; Niang, A.; Nichols, C.; Olack, B.; Pak, G.; Panzner, U.; Park, J.; Park, S.; Rabezanahary, H.; Rakotozandrindrainy, R.; Raminosoa, T.; Razafindrabe, T.; Sampo, E.; Schütt-Gerowitt, H.; Sow, A.; Sarpong, N.; Seo, H.; Sooka, A.; Soura, A.; Tall, A.; Teferi, M.; Thriemer, K.; Warren, M.; Yeshitela, B.; Clemens, J.; Wierzba, T. (2017)© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Background Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, ...
Spatial and temporal patterns of locally-acquired dengue transmission in Northern Queensland, Australia, 1993-2012Naish, S.; Dale, P.; Mackenzie, John; McBride, J.; Mengersen, K.; Tong, S. (2014)Background: Dengue has been a major public health concern in Australia since it re-emerged in Queensland in 1992–1993. We explored spatio-temporal characteristics of locally-acquired dengue cases in northern tropical ...
Persistently high rates of preterm and small-for-gestational-age over two decades within regional Western Australia: A spatio-temporal studyBall, S.; Pereira, Gavin (2013)This study assessed the temporal stability of spatial patterns in the incidence of preterm and small-for-gestational-age (SGA) in regional Western Australia, from 1987 to 2006. Using a time-stratified design, we characterised ...