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    Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis

    Access Status
    Fulltext not available
    Authors
    Hollier, Lauren
    Maybery, M.
    Keelan, J.
    Hickey, M.
    Whitehouse, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Hollier, L. and Maybery, M. and Keelan, J. and Hickey, M. and Whitehouse, A. 2014. Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis. Biological Psychology. 103: pp. 48-53.
    Source Title
    Biological Psychology
    DOI
    10.1016/j.biopsycho.2014.08.009
    ISSN
    0301-0511
    URI
    http://hdl.handle.net/20.500.11937/15205
    Collection
    • Curtin Research Publications
    Abstract

    Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind–Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typical lateralisation (callosal hypothesis). The current study examined the relationship between cord testosterone concentrations and cerebral laterality for language and spatial memory in adulthood. Male participants with high (>0.15 nmol) and low (<0.10 nmol) cord testosterone levels were invited to take part in the study (n = 18 in each group). Cerebral laterality was measured using functional Transcranial Doppler ultrasonography, while participants completed word generation and visual short-term memory tasks. Typical left lateralisation of language was more common in the high-testosterone group than in the low-testosterone group, χ2 = 4.50, df = 1, p = 034. Spatial memory laterality was unrelated to cord testosterone level. Our findings indicate that foetal testosterone exposure is related to language laterality in a direction that supports the callosal hypothesis.

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