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dc.contributor.authorChen, W.
dc.contributor.authorGaisina, I.
dc.contributor.authorGunosewoyo, Hendra
dc.contributor.authorMalekiani, S.
dc.contributor.authorHanania, T.
dc.contributor.authorKozikowski, A.
dc.date.accessioned2017-01-30T11:50:19Z
dc.date.available2017-01-30T11:50:19Z
dc.date.created2014-02-17T20:00:50Z
dc.date.issued2011
dc.identifier.citationChen, Wenwen and Gaisina, Irina N. and Gunosewoyo, Hendra and Malekiani, Sam A. and Hanania, Taleen and Kozikowski, Alan P. 2011. Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects. ChemMedChem. 6 (9): pp. 1587-1592.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/15540
dc.identifier.doi10.1002/cmdc.201100231
dc.description.abstract

A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose–response curve for neuroprotection in the homocysteic acid model of oxidative stress (graph shown), and furthermore, blocked chemically induced mania-like effects in mice.

dc.publisherWiley-VCH Verlag GmbH & Co. KGaA
dc.subjectkinase selectivity
dc.subjectmania
dc.subjectGSK-3
dc.subjectneuroprotection
dc.subjectbipolar disorders
dc.titleStructure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects
dc.typeJournal Article
dcterms.source.volume6
dcterms.source.number9
dcterms.source.startPage1587
dcterms.source.endPage1592
dcterms.source.issn1860-7179
dcterms.source.titleChemMedChem
curtin.department
curtin.accessStatusFulltext not available


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