Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects
| dc.contributor.author | Chen, W. | |
| dc.contributor.author | Gaisina, I. | |
| dc.contributor.author | Gunosewoyo, Hendra | |
| dc.contributor.author | Malekiani, S. | |
| dc.contributor.author | Hanania, T. | |
| dc.contributor.author | Kozikowski, A. | |
| dc.date.accessioned | 2017-01-30T11:50:19Z | |
| dc.date.available | 2017-01-30T11:50:19Z | |
| dc.date.created | 2014-02-17T20:00:50Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Chen, Wenwen and Gaisina, Irina N. and Gunosewoyo, Hendra and Malekiani, Sam A. and Hanania, Taleen and Kozikowski, Alan P. 2011. Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects. ChemMedChem. 6 (9): pp. 1587-1592. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/15540 | |
| dc.identifier.doi | 10.1002/cmdc.201100231 | |
| dc.description.abstract |
A new craze! A new chemical scaffold, namely a staurosporine-like molecule (shown) possessing a pyrazolone core, was found to be highly selective for glycogen synthase kinase 3 over a group of other homologous kinases, including typical cyclin-dependent kinases. This compound gave an impressive dose–response curve for neuroprotection in the homocysteic acid model of oxidative stress (graph shown), and furthermore, blocked chemically induced mania-like effects in mice. | |
| dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA | |
| dc.subject | kinase selectivity | |
| dc.subject | mania | |
| dc.subject | GSK-3 | |
| dc.subject | neuroprotection | |
| dc.subject | bipolar disorders | |
| dc.title | Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3ß Inhibitor: A Superior Neuroprotective Pyrazolone Showing Antimania Effects | |
| dc.type | Journal Article | |
| dcterms.source.volume | 6 | |
| dcterms.source.number | 9 | |
| dcterms.source.startPage | 1587 | |
| dcterms.source.endPage | 1592 | |
| dcterms.source.issn | 1860-7179 | |
| dcterms.source.title | ChemMedChem | |
| curtin.department | ||
| curtin.accessStatus | Fulltext not available |