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    Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat

    194824_75186_Al-Salami_Jnl_DiabRes_2013.pdf (706.7Kb)
    Access Status
    Open access
    Authors
    Lalic-Popovic, M.
    Vasovic, V.
    Milijasevic, B.
    Golocorbin-Kon, S.
    Al-Salami, Hani
    Mikov, M.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Lalic-Popovic, Mladena and Vasovic, Velibor and Milijasevic, Boris and Golocorbin-Kon, Svetlana and Al-Salami, Hani and Mikov, Momir. 2013. Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat. Journal of Diabetes Research. 2013: Article ID 598603: pp. 1-8.
    Source Title
    Journal of Diabetes Research
    DOI
    10.1155/2013/598603
    ISSN
    2314-6745
    Remarks

    This work is published under a Creative Commons Attribution Licence 3.0 http://creativecommons.org/licenses/by/3.0/au/

    URI
    http://hdl.handle.net/20.500.11937/15627
    Collection
    • Curtin Research Publications
    Abstract

    Major problem for diabetic patients represents damage of blood vessels and the oxidative stress of the brain cells due to increased concentration of free radicals and poor nutrition of brain cells. Gliclazide has antioxidative properties and poor blood brain barrier (BBB) penetration. Bile acids are known for their hypoglycemic effect and as promoters of drug penetration across biological membranes. Accordingly, the aim of this study is to investigate whether the bile acid (deoxycholic acid) can change the permeation of gliclazide, through the blood brain barrier of a rat model type-1 diabetes. Twenty-four male Wistar rats were randomly allocated to four groups, of which, two were given alloxan intraperitoneally (100 mg/kg) to induce diabetes. One diabetic group and one healthy group were given a bolus gliclazide intra-arterially (20 mg/kg), while the other two groups apart from gliclazide got deoxycholic acid (4 mg/kg) subcutaneously. Blood samples were collected 30, 60, 150, and 240 seconds after dose, brain tissues were immediately excised and blood glucose and gliclazide concentrations were measured. Penetration of gliclazide in groups without deoxycholic acid pretreatment was increased in diabetic animals compared to healthy animals. Also in both, the healthy and diabetic animals, deoxycholic acid increased the permeation of gliclazide through that in BBB.

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