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dc.contributor.authorAhmad, N.
dc.contributor.authorMohd Amin, M.C.
dc.contributor.authorMohd Mahali, S.
dc.contributor.authorIsmail, I.
dc.contributor.authorChuang, Victor
dc.identifier.citationAhmad, N. and Mohd Amin, M.C. and Mohd Mahali, S. and Ismail, I. and Chuang, V. 2014. Biocompatible and mucoadhesive bacterial cellulose-g-poly(acrylic acid) hydrogels for oral protein delivery. Molecular Pharmaceutics. 11: pp. 4130-4142.

Stimuli-responsive bacterial cellulose-g-poly-(acrylic acid) hydrogels were investigated for their potential use as an oral delivery system for proteins. These hydrogels were synthesized using electron beam irradiation without any cross-linking agents, thereby eliminating any potential toxic effects associated with cross-linkers. Bovine serum albumin (BSA), a model protein drug, was loaded into the hydrogels, and the release profile in simulated gastrointestinal fluids was investigated. Cumulative release of less than 10% in simulated gastric fluid (SGF) demonstrated the potential of these hydrogels to protect BSA from the acidic environment of the stomach. Subsequent conformational stability analyses of released BSA by SDS-PAGE, circular dichroism, and an esterase activity assay indicated that the structural integrity and bioactivity of BSA was maintained and preserved by the hydrogels. Furthermore, an increase in BSA penetration across intestinal mucosa tissue was observed in an ex vivo penetration experiment. Our fabricated hydrogels exhibited excellent cytocompatibility and showed no sign of toxicity, indicating the safety of these hydrogels for in vivo applications.

dc.publisherAmerican Chemical Society
dc.subjectprotein conformational stability
dc.subjectbacterial cellulose
dc.subjectoral protein delivery
dc.subjectelectron beam
dc.titleBiocompatible and mucoadhesive bacterial cellulose-g-poly(acrylic acid) hydrogels for oral protein delivery.
dc.typeJournal Article
dcterms.source.titleMolecular Pharmaceutics
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available

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