Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions

    Access Status
    Open access via publisher
    Authors
    Kalinina, Svetlana
    Elkina, Olga
    Kalinin, Dmitrii
    Syropyatov, Boris
    Dolzhenko, Anton
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Kalinina, Svetlana and Elkina, Olga and Kalinin, Dmitrii and Syropyatov, Boris and Dolzhenko, Anton. 2014. Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions. Pharmaceutical Biology. 52 (2): pp. 191-198.
    Source Title
    Pharmaceutical Biology
    DOI
    10.3109/13880209.2013.822001
    ISSN
    1388-0209
    URI
    http://hdl.handle.net/20.500.11937/15660
    Collection
    • Curtin Research Publications
    Abstract

    CONTEXT: Verbascum nigrum L. (Scrophulariaceae) is a perennial plant used in folk medicine for the treatment of kidney diseases due to its presumable diuretic properties. OBJECTIVE: We investigated the diuretic activity and toxicity of extracts from different parts of V. nigrum and identified a group of compounds responsible for the biological effect. MATERIALS AND METHODS: Five ethanol extracts from herb, roots, flowers, leaves and stems as well as five fractions of polar compounds isolated from herb of V. nigrum were orally administrated as a single dose of 50 mg/kg to rats. Urinary excretion and electrolyte content were measured at 3 and 6 h after the treatment. The acute toxicity of the V. nigrum extracts and fractions was evaluated in mice.RESULTS: All extracts, except the one prepared from the roots, showed a significant increase of the urine output within first 3 h after their administration. The extract from stems was the most active, inducing urine output of 14.6 ± 0.8 ml/kg BW versus 5.2 ± 1.4 ml/kg BW of the control. It also demonstrated saluretic activity with a natriuretic index 4.1 and a kaliuretic index 3.8. The diuretic activity was correlated with the flavonoid content in the plant organs. Flavonoid fractions demonstrated significant activity; the higher content of flavonoids (expressed as hesperidin) translated into more pronounced diuretic (35.9 ± 2.1 ml/kg BW) and saluretic effects (natriuretic index 4.5 and kaliuretic index 5.4). CONCLUSION: The diuretic activity of traditionally used V. nigrum was validated experimentally. The pharmacological effect was attributed to flavonoids, which accumulated in aerial parts of the plant, mainly in stems.

    Related items

    Showing items related by title, author, creator and subject.

    • In-vitro, antiviral, antimicrobial and antioxidant potential activity of Tomato pomace
      Gaafar, A.; Asker, M.; Salama, Z.; Bagato, O.; Ali, Mohammed (2015)
      © 2015, Global Research Online. All rights reserved. This work aimed to evaluate the efficiency of different organic solvents such as, aqueous, ethanol and acetone for extraction of phenolic, flavonoid and tannin compounds ...
    • Size exclusion chromatography as a tool for natural organic matter characterisation in drinking water treatment
      Allpike, Bradley (2008)
      Natural organic matter (NOM), ubiquitous in natural water sources, is generated by biogeochemical processes in both the water body and in the surrounding watershed, as well as from the contribution of organic compounds ...
    • Acute heart failure admissions in New South Wales and the Australian Capital Territory: the NSW HF Snapshot Study
      Newton, P.; Davidson, P.; Reid, Christopher; Krum, H.; Hayward, C.; Sibbritt, D.; Banks, E.; MacDonald, P. (2016)
      Objective: The primary aim of the NSW Heart Failure (HF) Snapshot was to obtain a representative cross-sectional view of patients with acute HF and their management in New South Wales and Australian Capital Territory ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.