International Perspectives on the Cost-Effectiveness of Tandem Mass Spectrometry for Rare Metabolic Conditions
MetadataShow full item record
Objectives: To examine and evaluate the economic evidence regarding the use of tandem mass spectrometry (MS/MS) for the detection of rare metabolic conditions in neonates, and then to consider the transferability of these national-level results to other decision-making contexts.Methods: A systematic literature review was undertaken, identifying papers published between January 1997 and March 2008. Thirteen unique cost-effectiveness evaluations were identified and appraised forcomparability and transferability of results across settings.Results: The primary outcome measure was usually life years gained (LYG) or quality adjusted lifeyears gained (QALY). The incremental cost-effectiveness ratios (ICER) presented were generally supportive of MS/MS, but showed considerable variation. Differences in assumptions made regarding prevalence and prognosis played a significant role in this variation.Conclusions: Differences in study structure, the approach to costing, the choice of intervention, control and outcome measure, and the limit of studies to developed countries makes international generalisation of the cost-effectiveness evidence difficult. The importance of assumptions regarding disease progression and subsequent health care utilisation suggests that further work needs to consider the importance of longer-term follow-up.
Showing items related by title, author, creator and subject.
Ciketic, S.; Hayatbakhsh, R.; McKetin, Rebecca; Doran, C.; Najman, J. (2015)© 2015 Informa UK Ltd. Introduction and aims: Illicit methamphetamine (MA) use is an important public health concern. There is a dearth of knowledge about effective and cost-effective treatments for methamphetamine (MA) ...
Lansdorp_Vogelaar, Iris; Knudsen, A.; Brenner, H. (2011)Colorectal cancer is an important public health problem. Several screening methods have been shown to be effective in reducing colorectal cancer mortality. The objective of this review was to assess the cost-effectiveness ...
Colegate, Timothy Maarten (2012)The Square Kilometre Array (SKA) radio telescope is being designed as a premier scientific instrument of the 21st century, using novel technologies to maximise its scientific capability. The SKA has an aggressive project ...